Genome Editing of Plants

被引：76

作者：

Songstad, D. D. ^{[1
]}

Petolino, J. F. ^{[2
]}

Voytas, D. F. ^{[3
]}

Reichert, N. A. ^{[4
]}

机构：

[1] Cibus LLC, 6455 Nancy Ridge Dr, San Diego, CA 92121 USA

[2] Ivy Tech Community Coll, Dept Biotechnol, Indianapolis, IN USA

[3] Univ Minnesota, Dept Genet Cell Biol & Dev, St Paul, MN 55108 USA

[4] Mississippi State Univ, Dept Biol Sci, Mississippi State, MS 39762 USA

来源：

CRITICAL REVIEWS IN PLANT SCIENCES | 2017年 / 36卷 / 01期

关键词：

Biological mutagenesis; chemical mutagenesis; CRISPR; knock-in; knock-out; ODM; RTDS; single nucleotide polymorphism; SNP; TALENs; ZFN; DOUBLE-STRAND BREAKS; QUANTITATIVE-TRAIT LOCI; HOMOLOGOUS RECOMBINATION; ARABIDOPSIS-THALIANA; TRANSPOSABLE ELEMENT; TARGETED MUTAGENESIS; INDUCED MUTATIONS; INSERTIONAL MUTAGENESIS; NICOTIANA-BENTHAMIANA; TRANSGENE INTEGRATION;

D O I：

10.1080/07352689.2017.1281663

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Genome editing in organisms via random mutagenesis is a naturally occurring phenomenon. As a technology, genome editing has evolved from the use of chemical and physical mutagenic agents capable of altering DNA sequences to biological tools such as designed sequence-specific nucleases (SSN) to produce knock-out (KO) or knock-in (KI) edits and Oligonucleotide Directed Mutagenesis (ODM) where specific nucleotide changes are made in a directed manner resulting in custom single nucleotide polymorphisms (SNPs). Cibus' SU Canola, which the US Department of Agriculture (USDA) views as non-genetically modified (non-GM), is Cibus' first commercial product arising from plant genome editing and had its test launch in 2014. Regulatory aspects of the various genome editing tools will be discussed.

引用

页码：1 / 23

页数：23

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