Piezoelectrical shear-force control on soft biological samples in aqueous solution

被引：14

作者：

Brunner, R ^{[1
]}

Hering, O ^{[1
]}

Marti, O ^{[1
]}

Hollricher, O ^{[1
]}

机构：

[1] Univ Ulm, Expt Phys Abt, D-89069 Ulm, Germany

来源：

APPLIED PHYSICS LETTERS | 1997年 / 71卷 / 25期

关键词：

D O I：

10.1063/1.120462

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

In order to apply scanning near-field optical microscopy to life science, it is essential to have an accurate distance feedback that also works on soft biological samples in liquids. In this letter, we report measurements of neuron cells in aqueous solution using an advanced piezoelectrical shear-force detection setup. Simultaneously obtained topographical and fluorescence images are presented, demonstrating a resolution below 100 nm in the optical image, The influence of the water level on the shear-force signal and the interaction between near-field probe and soft organic samples an discussed. Stable feedback in fluids is obtained with tip-sample interaction forces below 100 pN. (C) 1997 American Institute of Physics. [S0003-6951(97)01751-8].

引用

页码：3628 / 3630

页数：3

共 13 条

[1] COMBINED SHEAR FORCE AND NEAR-FIELD SCANNING OPTICAL MICROSCOPY [J].