Lipase-mediated asymmetric construction of 2-arylpropionic acids: enantiocontrolled syntheses of S-naproxen and S-ibuprofen

被引：29

作者：

Bando, T ^{[1
]}

Namba, Y ^{[1
]}

Shishido, K ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,INST MED RESOURCES,TOKUSHIMA 770,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(97)00237-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A general and enantiocontrolled synthetic route to 2-arylpropionic acids, represented by non-steroidal anti-inflammatory drugs S-naproxen 1a and S-ibuprofen 1b, has been developed by employing the lipase-mediated asymmetric acetylation of prochiral 2-aryl-1,3-propanediol 3, which has been derived via a Heck reaction, as the key step. (C) 1997 Elsevier Science Ltd.

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页码：2159 / 2165

页数：7

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