A NEW CHALCONE AND ANTIOXIDANT CONSTITUENTS OF Glycyrrhiza glabra

被引：14

作者：

Chen, Jih-Jung ^{[1
,2
]}

Cheng, Ming-Jen ^{[3
]}

Shu, Chih-Wen ^{[4
]}

Sung, Ping-Jyun ^{[5
]}

Lim, Yun-Ping ^{[6
]}

Cheng, Lin-Yang ^{[7
]}

Wang, Sin-Ling ^{[7
]}

Chen, Li-Chai ^{[8
,9
]}

机构：

[1] Natl Yang Ming Univ, Sch Pharmaceut Sci, Fac Pharnacy, Taipei 112, Taiwan

[2] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[3] FIRDI, BCRC, Hsinchu 300, Taiwan

[4] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan

[5] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[6] China Med Univ, Coll Pharm, Sch Pharm, Taichung 404, Taiwan

[7] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan

[8] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan

[9] Kaohsiung Armed Forces Gen Hosp, Zuoying Branch, Dept Pharm, Kaohsiung 813, Taiwan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2017年 / 53卷 / 04期

关键词：

Glycyrrhiza glabra; chalcone; glycyglabrone; antioxidant activity;

D O I：

10.1007/s10600-017-2077-1

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A new chalcone, glycyglabrone (1), has been isolated from the roots of Glycyrrhiza glabra, together with three known compounds, licoagrochalcone B (2), licochalcone C (3), and kanzonol Y (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Glycyglabrone (1) and licochalcone C (3) exhibited potent free radical scavenging activity, with IC0.200 values of 4.6 +/- 0.6 and 8.2 +/- 0.9 mu M, respectively, in the diphenylpicrylhydrazyl radical (DPPH) decoloration assay.

引用

页码：632 / 634

页数：3

共 7 条

[1]

2 PRENYLATED RETROCHALCONES FROM GLYCYRRHIZA-INFLATA [J].

KAJIYAMA, K ;

DEMIZU, S ;

HIRAGA, Y ;

KINOSHITA, K ;

KOYAMA, K ;

TAKAHASHI, K ;

TAMURA, Y ;

OKADA, K ;

KINOSHITA, T .

PHYTOCHEMISTRY, 1992, 31 (09) :3229-3232

[2]

Anti-Tubercular Agents from Glycyrrhiza glabra [J].

Kalani, Komal ;

Chaturvedi, Vinita ;

Alam, Sarfaraz ;

Khan, Feroz ;

Srivastava, Santosh Kumar .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2015, 15 (11) :1043-1049

[3]

In Silico and In Vivo Anti-Malarial Studies of 18β Glycyrrhetinic Acid from Glycyrrhiza glabra [J].

Kalani, Komal ;

Agarwal, Jyoti ;

Alam, Sarfaraz ;

Khan, Feroz ;

Pal, Anirban ;

Srivastava, Santosh Kumar .

PLOS ONE, 2013, 8 (09)

[4]

KO FN, 1995, BBA-LIPID LIPID MET, V1258, P145

[5]

Flavonoid constituents from Glycyrrhiza glabra hairy root cultures [J].

Li, W ;

Asada, Y ;

Yoshikawa, T .

PHYTOCHEMISTRY, 2000, 55 (05) :447-456

[6]

LACIDIPINE - A DIHYDROPYRIDINE CALCIUM-ANTAGONIST WITH ANTIOXIDANT ACTIVITY [J].

VANAMSTERDAM, FTM ;

ROVERI, A ;

MAIORINO, M ;

RATTI, E ;

URSINI, F .

FREE RADICAL BIOLOGY AND MEDICINE, 1992, 12 (03) :183-187

[7]

Bioactive constituents of oleanane-type triterpene saponins from the roots of Glycyrrhiza glabra [J].

Wei, Juan-Hua ;

Zheng, Yun-Feng ;

Li, Cun-Yu ;

Tang, Yu-Ping ;

Peng, Guo-Ping .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2014, 16 (11) :1044-1053

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