Preparation of 5-hydroxy-1-alkenyboronates from 1-alkynylboronates, Cp2ZrCl2/2EtMgBr, and aldehydes

被引：20

作者：

Quntar, AA ^{[1
]}

Srebnik, M ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Dept Nat Prod & Med Chem, IL-91120 Jerusalem, Israel

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 23期

关键词：

D O I：

10.1021/ol0483504

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Alkynylboronates form five-membered zirconacycles with Cp2ZrCl2/2-EtMgBr as indicated by deuterium labeling. The zirconacycles add aldehydes to form seven-membered zirconacycles. Hydrolysis of the latter provides 5-hydroxy-1-alkenylboronates in fair to good isolated yields. Both aliphatic and aromatic aldehydes undergo insertion.

引用

页码：4243 / 4244

页数：2

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