Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone

被引：33

作者：

Aida, K

Tawata, M

Negishi, M

Onaya, T ^{[1
]}

机构：

[1] Yamanashi Med Univ, Dept Internal Med 3, Tamaho, Yamanashi 40938, Japan

[2] NIEHS, Reprod & Dev Toxicol Lab, NIH, Res Triangle Pk, NC 27709 USA

来源：

HORMONE AND METABOLIC RESEARCH | 1997年 / 29卷 / 12期

关键词：

growth hormone; mouse glycine N-methyltransferase; sexual; dimorphism;

D O I：

10.1055/s-2007-978982

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The secretion pattern of putuitary growth hormone (GH) in rodents is sexually dimorphic and regulates the expression of some hepatic genes. We report cloning of mouse glycine N-methyltransferase (GNMT) cDNA. The mouse GNMT mRNA is expressed at much lower levels in male than in female livers. Hypophysectomy in male mice resulted in as a high level of the expression as in female mice. Treatment with GH of hypophysectomized male mice twice a day for 5 days decreased the expression. These results indicate that the sex difference of the mouse GNMT expression is regulated by GH secretion patterns.

引用

页码：646 / 649

页数：4

共 24 条

[21] INTERMITTENT PLASMA GROWTH-HORMONE TRIGGERS TYROSINE PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF A LIVER-EXPRESSED, STAT 5-RELATED DNA-BINDING PROTEIN - PROPOSED ROLE AS AN INTRACELLULAR REGULATOR OF MALE-SPECIFIC LIVER GENE-TRANSCRIPTION [J].