The biology and function of exosomes in cancer

被引：1851

作者：

Kalluri, Raghu ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Metastasis Res Ctr, Houston, TX 77030 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2016年 / 126卷 / 04期

关键词：

TUMOR-DERIVED EXOSOMES; MESSENGER-RNAS; TRANSFERRIN RECEPTOR; HORIZONTAL TRANSFER; STEM-CELLS; T-CELLS; MICROVESICLES; SECRETION; VESICLES; BIOGENESIS;

D O I：

10.1172/JCI81135

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Humans circulate quadrillions of exosomes at all times. Exosomes are a class of extracellular vesicles released by all cells, with a size range of 40-150 nm and a lipid bilayer membrane. Exosomes contain DNA, RNA, and proteins. Exosomes likely remove excess and/or unnecessary constituents from the cells, functioning like garbage bags, although their precise physiological role remains unknown. Additionally, exosomes may mediate specific cell-to-cell communication and activate signaling pathways in cells they fuse or interact with. Exosomes are detected in the tumor microenvironment, and emerging evidence suggests that they play a role in facilitating tumorigenesis by regulating angiogenesis, immunity, and metastasis. Circulating exosomes can be used as liquid biopsies and noninvasive biomarkers for early detection, diagnosis, and treatment of cancer patients.

引用

页码：1208 / 1215

页数：8

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