mTOR and cancer: many loops in one pathway

被引：343

作者：

Efeyan, Alejo ^{[1
,2
]}

Sabatini, David M. ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Howard Hughes Med Inst, Dept Biol, Cambridge, MA 02139 USA

[3] MIT, Koch Inst Integrat Res Canc, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 02期

关键词：

PROTEIN-KINASE; CELL-GROWTH; METABOLIC CHECKPOINT; MAMMALIAN TARGET; BINDING PARTNER; RAG GTPASES; COMPLEX; RAPAMYCIN; PHOSPHORYLATION; INHIBITION;

D O I：

10.1016/j.ceb.2009.10.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last years, a significant number of pieces have been added to the puzzle of how mTOR coordinates and executes its functions. Extensive research on mTOR has also uncovered a complex network of regulatory loops that impact the therapeutic approaches aimed at targeting mTOR.

引用

页码：169 / 176

页数：8

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