Targeted delivery to the pilosebaceous unit via liposomes

被引：62

作者：

Lauer, AC ^{[1
]}

Ramachandran, C ^{[1
]}

Lieb, LM ^{[1
]}

Niemiec, S ^{[1
]}

Weiner, ND ^{[1
]}

机构：

[1] UNIV MICHIGAN, COLL PHARM, ANN ARBOR, MI 48109 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1996年 / 18卷 / 03期

关键词：

topical application; pilosebaceous unit; hair follicle; sebaceous gland; liposome; nonionic liposome; phospholipid;

D O I：

10.1016/0169-409X(95)00089-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The significance of the pilosebaceous unit (hair follicle and sebaceous glands) as a route for passive drug delivery into the skin remains a controversial subject. The pilosebaceous unit is a complex, dynamic structure, which is the site of unique biochemical, metabolical and immunological events. Recent topical delivery studies have employed increasingly systematic, quantitative methodologies in attempts to define the follicular pathway. Targeting specific sites of the hair follicle may represent a feasible therapeutic approach, as several dermatological abnormalities are known to originate at the hair follicle. In a growing number of topical delivery studies, liposomes have been shown to target drug delivery to the pilosebaceous unit. This review will describe general aspects of follicular delivery, with a particular focus an studies which have demonstrated targeted follicular delivery via liposomes.

引用

页码：311 / 324

页数：14

共 48 条

[21] FOLLICULAR (PILOSEBACEOUS UNIT) DEPOSITION AND PHARMACOLOGICAL BEHAVIOR OF CIMETIDINE AS A FUNCTION OF FORMULATION [J].