Chronic DLL4 blockade induces vascular neoplasms

被引:232
作者
Yan, Minhong [1 ]
Callahan, Christopher A. [2 ]
Beyer, Joseph C. [2 ]
Allamneni, Krishna P. [3 ]
Zhang, Gu [1 ]
Ridgway, John Brady [1 ]
Niessen, Kyle [1 ]
Plowman, Greg D. [1 ]
机构
[1] Genentech Inc, Dept Tumor Biol & Angiogenesis, San Francisco, CA 94080 USA
[2] Genentech Inc, Dept Pathol, San Francisco, CA 94080 USA
[3] Genentech Inc, Dept Toxicol, San Francisco, CA 94080 USA
关键词
INHIBITS TUMOR-GROWTH; ENDOTHELIAL-CELLS; ANGIOGENESIS; MIGRATION;
D O I
10.1038/nature08751
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Arising from: J. Ridgway et al.Nature444, 1083–1087 (2006)10.1038/nature05313
引用
收藏
页码:E6 / E7
页数:2
相关论文
共 9 条
[1]  
[Anonymous], PHASE 1 DOSE ESCALAT
[2]  
[Anonymous], A Multiple Ascending Dose Phase I Study of SB 9200 in Treatment Naive Adults With Chronic Hepatitis C Infection
[3]   Promoting angiogenesis to a fault [J].
Hicklin, Daniel J. .
NATURE BIOTECHNOLOGY, 2007, 25 (03) :300-302
[4]   Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells [J].
Hsieh, S. H. ;
Ying, N. W. ;
Wu, M. H. ;
Chiang, W. F. ;
Hsu, C. L. ;
Wong, T. Y. ;
Jin, Y. T. ;
Hong, T. M. ;
Chen, Y. L. .
ONCOGENE, 2008, 27 (26) :3746-3753
[5]   Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications [J].
Li, Ji-Liang ;
Harris, Adrian L. .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 :3094-3110
[6]   Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis [J].
Noguera-Troise, Irene ;
Daly, Christopher ;
Papadopoulos, Nicholas J. ;
Coetzee, Sandra ;
Boland, Pat ;
Gale, Nicholas W. ;
Lin, Hsin Chieh ;
Yancopoulos, George D. ;
Thurston, Gavin .
NATURE, 2006, 444 (7122) :1032-1037
[7]   Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis [J].
Ridgway, John ;
Zhang, Gu ;
Wu, Yan ;
Stawicki, Scott ;
Liang, Wei-Ching ;
Chanthery, Yvan ;
Kowalski, Joe ;
Watts, Ryan J. ;
Callahan, Christopher ;
Kasman, Ian ;
Singh, Mallika ;
Chien, May ;
Tan, Christine ;
Hongo, Jo-Anne S. ;
de Sauvage, Fred ;
Plowman, Greg ;
Yan, Minhong .
NATURE, 2006, 444 (7122) :1083-1087
[8]   EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution [J].
Schmidt, Maike ;
Paes, Kim ;
De Maziere, Ann ;
Smyczek, Tanya ;
Yang, Stacey ;
Gray, Alane ;
French, Dorothy ;
Kasman, Ian ;
Klumperman, Judith ;
Rice, Dennis S. ;
Ye, Weilan .
DEVELOPMENT, 2007, 134 (16) :2913-2923
[9]  
SETONROGERS S, 2007, NATURE REV CANC, V7, P72