The MAK-V protein kinase regulates endocytosis in mouse

被引：15

作者：

Korobko, IV ^{[1
]}

Korobko, EV ^{[1
]}

Kiselev, SL ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Gene Biol, Moscow 117334, Russia

来源：

MOLECULAR AND GENERAL GENETICS | 2000年 / 264卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

protein kinase; endocytosis; rabaptin-5; human chromosome 21q22.11;

D O I：

10.1007/s004380000293

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the cloning of a mouse cDNA encoding the MAK-V protein kinase, with a putative specificity for serine/threonine residues. The mak-v gene is transcribed in adult brain and in the mouse embryo from at least 7.5 dpc. Using the yeast two-hybrid system, we showed that MAK-V interacts with Rabaptin-5, a protein which plays an important role in endocytosis. Functional studies of the MAK-V protein suggest that it regulates endocytosis. We also constructed a human mak-v cDNA and localized the human mak-v gene at 21q22.11. Its chromosomal location suggests that mak-v could be involved in disorders of the nervous system, development or in malignancies.

引用

页码：411 / 418

页数：8

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