The MAK-V protein kinase regulates endocytosis in mouse

被引：15

作者：

Korobko, IV ^{[1
]}

Korobko, EV ^{[1
]}

Kiselev, SL ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Gene Biol, Moscow 117334, Russia

来源：

MOLECULAR AND GENERAL GENETICS | 2000年 / 264卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

protein kinase; endocytosis; rabaptin-5; human chromosome 21q22.11;

D O I：

10.1007/s004380000293

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the cloning of a mouse cDNA encoding the MAK-V protein kinase, with a putative specificity for serine/threonine residues. The mak-v gene is transcribed in adult brain and in the mouse embryo from at least 7.5 dpc. Using the yeast two-hybrid system, we showed that MAK-V interacts with Rabaptin-5, a protein which plays an important role in endocytosis. Functional studies of the MAK-V protein suggest that it regulates endocytosis. We also constructed a human mak-v cDNA and localized the human mak-v gene at 21q22.11. Its chromosomal location suggests that mak-v could be involved in disorders of the nervous system, development or in malignancies.

引用

页码：411 / 418

页数：8

共 29 条

[11]

Hardie G, 1995, PROTEIN KINASE FACTS, V2

[12] The Habicht approach to subresultants [J].

Ho, CJ ;

Yap, CK .

JOURNAL OF SYMBOLIC COMPUTATION, 1996, 21 (01) :1-14

[13] PHOSPHORYLATION OF RABPHILIN-3A BY CALMODULIN-DEPENDENT PROTEIN-KINASE-II [J].

KATO, M ;

SASAKI, T ;

IMAZUMI, K ;

TAKAHASHI, K ;

ARAKI, K ;

SHIRATAKI, H ;

MATSUURA, Y ;

ISHIDA, A ;

FUJISAWA, H ;

TAKAI, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 205 (03) :1776-1784

[14] Molecular cloning and characterization of the mouse tag7 gene encoding a novel cytokine [J].

Kiselev, SL ;

Kustikova, OS ;

Korobko, EV ;

Prokhortchouk, EB ;

Kabishev, AA ;

Lukanidin, EM ;

Georgiev, GP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (29) :18633-18639

[15] DOWN-SYNDROME PHENOTYPES - THE CONSEQUENCES OF CHROMOSOMAL IMBALANCE [J].

KORENBERG, JR ;

CHEN, XN ;

SCHIPPER, R ;

SUN, Z ;

GONSKY, R ;

GERWEHR, S ;

CARPENTER, N ;

DAUMER, C ;

DIGNAN, P ;

DISTECHE, C ;

GRAHAM, JM ;

HUGDINS, L ;

MCGILLIVRAY, B ;

MIYAZAKI, K ;

OGASAWARA, N ;

PARK, JP ;

PAGON, R ;

PUESCHEL, S ;

SACK, G ;

SAY, B ;

SCHUFFENHAUER, S ;

SOUKUP, S ;

YAMANAKA, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4997-5001

[16]

Korobko EV, 2000, DOKL AKAD NAUK+, V370, P119

[17]

Korobko IV, 1997, DOKL AKAD NAUK+, V354, P554

[18] THE SCANNING MODEL FOR TRANSLATION - AN UPDATE [J].

KOZAK, M .

JOURNAL OF CELL BIOLOGY, 1989, 108 (02) :229-241

[19] EVIDENCE FOR PHOSPHATIDYLINOSITOL 3-KINASE AS A REGULATOR OF ENDOCYTOSIS VIA ACTIVATION OF RAB5 [J].

LI, GP ;

D'SOUZA-SCHOREY, C ;

BARBIERI, MA ;

ROBERTS, RL ;

KLIPPEL, A ;

WILLIAMS, LT ;

STAHL, PD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (22) :10207-10211

[20]

Lonart G, 1998, J NEUROSCI, V18, P634

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