Clinical utility of endothelial function testing - Ready for prime time?

被引：116

作者：

Kuvin, JT ^{[1
]}

Karas, RH ^{[1
]}

机构：

[1] Tufts Univ New England Med Ctr, Div Cardiol, Dept Med, Boston, MA 02111 USA

来源：

CIRCULATION | 2003年 / 107卷 / 25期

关键词：

D O I：

10.1161/01.CIR.0000075928.54461.33

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The treatment of rats with Boc-Asp-fmk (BAF), a pancaspase inhibitor, which was started on the third day after myocardial infarction, resulted in an alleviation of ventricular] remodeling and dysfunction during the chronic stage of 12 weeks after infarction by blocking apoptosis of granulation tissue cells consisting of myofibroblasts, fibroblasts, and small vessels in the old infarct areas, which accompanied thickening of the infarct wall. In addition, many of the α-smooth muscle actin-positive myofibroblast-like cells made bundles and were running parallel to the surviving cardiomyocytes in old infarcts of the BAF-treated hearts, which were (by electron microscopy) smooth muscle cells with contractile phenotype.

引用

页码：3243 / 3247

页数：5

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