Pot1 and telomere maintenance

被引：54

作者：

Baumann, Peter ^{[1
,2
]}

Price, Carolyn ^{[3
]}

机构：

[1] Stowers Inst Med Res, Howard Hughes Med Inst, Kansas City, MO 64110 USA

[2] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA

[3] Univ Cincinnati, Dept Canc & Cell Biol, Cincinnati, OH 45267 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 17期

关键词：

Pot1; Telomere; ACD; Telomerase; TEBP; SINGLE-STRANDED-DNA; ABERRANT HOMOLOGOUS RECOMBINATION; OXYTRICHA MACRONUCLEAR DNA; CHROMOSOME END-PROTECTION; CELL-CYCLE PROGRESSION; PROTEIN IN-VITRO; BINDING-PROTEIN; FISSION YEAST; PREVENTS ACTIVATION; DAMAGE CHECKPOINT;

D O I：

10.1016/j.febslet.2010.05.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteins that specifically bind the single-stranded overhang at the ends of telomeres have been identified in a wide range of eukaryotes and play pivotal roles in chromosome end protection and telomere length regulation. Here we summarize recent findings regarding the functions of POT1 proteins in vertebrates and discuss the functional evolution of POT1 proteins following gene duplication in protozoa, plants, nematodes and mice. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3779 / 3784

页数：6

共 82 条

[1] Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1 [J].

Armbruster, BN ;

Linardic, CM ;

Veldman, T ;

Bansal, NP ;

Downie, DL ;

Counter, CM .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (08) :3552-3561

[2] The structure and function of telomerase reverse transcriptase [J].

Autexier, Chantal ;

Lue, Neal F. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :493-517

[3] Human Pot1 (Protection of telomeres) protein: Cytolocalization, gene structure, and alternative splicing [J].

Baumann, P ;

Podell, E ;

Cech, TR .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (22) :8079-8087

[4] Pot1, the putative telomere end-binding protein in fission yeast and humans [J].

Baumann, P ;

Cech, TR .

SCIENCE, 2001, 292 (5519) :1171-1175

[5] Telomere maintenance in fission yeast requires an Est1 ortholog [J].

Beernink, HTH ;

Miller, K ;

Deshpande, A ;

Bucher, P ;

Cooper, JP .

CURRENT BIOLOGY, 2003, 13 (07) :575-580

[6] Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability [J].

Bunch, JT ;

Bae, NS ;

Leonardi, J ;

Baumann, P .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (13) :5567-5578

[7] Human telomeres have different overhang sizes at leading versus lagging strands [J].

Chai, WH ;

Du, Q ;

Shay, JW ;

Wright, WE .

MOLECULAR CELL, 2006, 21 (03) :427-435

[8] Telomere maintenance through spatial control of telomeric proteins [J].

Chen, Liuh-Yow ;

Liu, Dan ;

Zhou Songyang .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (16) :5898-5909

[9] Pot1 and cell cycle progression cooperate in telomere length regulation [J].

Churikov, Dmitri ;

Price, Carolyn M. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (01) :79-84

[10] Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection [J].

Churikov, Dmitri ;

Wei, Chao ;

Price, Carolyn M. .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (18) :6971-6982

← 1 2 3 4 5 6 7 8 9 →