Pot1 and telomere maintenance

被引：54

作者：

Baumann, Peter ^{[1
,2
]}

Price, Carolyn ^{[3
]}

机构：

[1] Stowers Inst Med Res, Howard Hughes Med Inst, Kansas City, MO 64110 USA

[2] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA

[3] Univ Cincinnati, Dept Canc & Cell Biol, Cincinnati, OH 45267 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 17期

关键词：

Pot1; Telomere; ACD; Telomerase; TEBP; SINGLE-STRANDED-DNA; ABERRANT HOMOLOGOUS RECOMBINATION; OXYTRICHA MACRONUCLEAR DNA; CHROMOSOME END-PROTECTION; CELL-CYCLE PROGRESSION; PROTEIN IN-VITRO; BINDING-PROTEIN; FISSION YEAST; PREVENTS ACTIVATION; DAMAGE CHECKPOINT;

D O I：

10.1016/j.febslet.2010.05.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteins that specifically bind the single-stranded overhang at the ends of telomeres have been identified in a wide range of eukaryotes and play pivotal roles in chromosome end protection and telomere length regulation. Here we summarize recent findings regarding the functions of POT1 proteins in vertebrates and discuss the functional evolution of POT1 proteins following gene duplication in protozoa, plants, nematodes and mice. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3779 / 3784

页数：6

共 82 条

[51] How Shelterin Protects Mammalian Telomeres [J].

Palm, Wilhelm ;

de Lange, Titia .

ANNUAL REVIEW OF GENETICS, 2008, 42 :301-334

[52] Cdc13 delivers separate complexes to the telomere for end protection and replication [J].

Pennock, E ;

Buckley, K ;

Lundblad, V .

CELL, 2001, 104 (03) :387-396

[53] The pot1+ homologue in Aspergillus nidulans is required for ordering mitotic events [J].

Pitt, CW ;

Moreau, E ;

Lunness, PA ;

Doonan, JH .

JOURNAL OF CELL SCIENCE, 2004, 117 (02) :199-209

[54] TELOMERIC DNA PROTEIN INTERACTIONS OF OXYTRICHA MACRONUCLEAR DNA [J].

PRICE, CM ;

CECH, TR .

GENES & DEVELOPMENT, 1987, 1 (08) :783-793

[55] DNA RECOGNITION AND BINDING BY THE EUPLOTES TELOMERE PROTEIN [J].

PRICE, CM ;

SKOPP, R ;

KRUEGER, J ;

WILLIAMS, D .

BIOCHEMISTRY, 1992, 31 (44) :10835-10843

[56]

Qi HY, 2000, GENE DEV, V14, P1777

[57] C-elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins [J].

Raices, Marcela ;

Verdun, Ramiro E. ;

Compton, Sarah A. ;

Haggblom, Candy I. ;

Griffith, Jack D. ;

Dillin, Andrew ;

Karlseder, Jan .

CELL, 2008, 132 (05) :745-757

[58] Arabidopsis POT1A interacts with TERT-V(18), an N-terminal splicing variant of telomerase [J].

Rossignol, Pascale ;

Collier, Sarah ;

Bush, Max ;

Shaw, Peter ;

Doonan, John H. .

JOURNAL OF CELL SCIENCE, 2007, 120 (20) :3678-3687

[59] Telomere-end processing: The terminal nucleotides of human chromosomes [J].

Sfeir, AJ ;

Chai, WH ;

Shay, JW ;

Wright, WE .

MOLECULAR CELL, 2005, 18 (01) :131-138

[60] POT1 proteins in green algae and land plants: DNA-binding properties and evidence of co-evolution with telomeric DNA [J].

Shakirov, Eugene V. ;

Song, Xiangyu ;

Joseph, Jessica A. ;

Shippen, Dorothy E. .

NUCLEIC ACIDS RESEARCH, 2009, 37 (22) :7455-7467

← 1 2 3 4 5 6 7 8 9 →