R(+)-8-OH-DPAT, a selective 5-HT1A receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex

被引：9

作者：

Kuroki, T

Dai, J

Meltzer, HY

Ichikawa, J

机构：

[1] Vanderbilt Univ, Sch Med, Dept Psychiat, Psychopharmacol Div,Floor Lab 1, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37212 USA

来源：

BRAIN RESEARCH | 2000年 / 872卷 / 1-2期

关键词：

R(+)-8-OH-DPAT; 5-HT1A receptor; D-amphetamine; dopamine synthesis; rat;

D O I：

10.1016/S0006-8993(00)02437-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

R(+)-8-OH-DPAT (0.05, but not 0.025, 0.1, 1 mg/kg), a 5-HT1A receptor agonist, decreased l-3,4-dihydroxyphenylalanine (DOPA) accumulation in rat striatum following NSD-1015, an l-aromatic amino acid decarboxylase inhibitor. Amphetamine (1 mg/kg) increased striatal DOPA accumulation, an effect attenuated by R(+)-8-OH-DPAT (0.05 mg/kg). However, both amphetamine (1 mg/kg) and R(+)-8-OH-DPAT (0.05 mg/kg) decreased cortical DOPA accumulation; there were no additional decreases from their combination. Neither amphetamine (1 mg/kg), R(+)-8-OH-DPAT (0.05 mg/kg), or the combination, significantly affected DOPA accumulation in the nucleus accumbens. The significance of and possible mechanisms for these findings are discussed. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：204 / 207

页数：4