Molecular events that regulate αβ versus γδ T cell lineage commitment:: old suspects, new players and different game plans

被引：11

作者：

Narayan, Kavitha ^{[1
]}

Kang, Joonsoo ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Worcester, MA 01655 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2007年 / 19卷 / 02期

关键词：

D O I：

10.1016/j.coi.2007.01.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The divergence of alpha beta and gamma delta T cells from a common precursor in the thymus is regulated by multiple cell-intrinsic and cell-extrinsic factors, most of which are not well defined. Recent studies have provided crucial data regarding the precise timing of lineage commitment and some clarification on the extent of the involvement of Notch and T-cell receptor signaling in this process. Combined with new insights into the differential regulation of molecular pathways active in alpha beta and gamma delta. precursors, these data have led to the generation of a revised model of lineage commitment.

引用

页码：169 / 175

页数：7

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