Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid

被引：37

作者：

Häussler, S

Rohde, M

von Neuhoff, N

Nimtz, M

Steinmetz, I

机构：

[1] Hannover Med Sch, Inst Med Microbiol, D-30625 Hannover, Germany

[2] Hannover Med Sch, Inst Cell & Mol Pathol, D-30625 Hannover, Germany

[3] German Res Ctr Biotechnol, Braunschweig, Germany

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 05期

关键词：

D O I：

10.1128/IAI.71.5.2970-2975.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.

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页码：2970 / 2975

页数：6

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