Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand

被引：35

作者：

Kang, Jung-Ah ^{[1
,2
,3
]}

Kim, Woo-Seok ^{[1
,2
,3
]}

Park, Sung-Gyoo ^{[1
,2
,3
]}

机构：

[1] GIST, Sch Life Sci, Gwangju 500712, South Korea

[2] GIST, Bio Imaging Res Ctr, Gwangju 500712, South Korea

[3] GIST, Immune Synapse Res Ctr, Gwangju 500712, South Korea

来源：

IMMUNOLOGY | 2014年 / 143卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

B cell; B-cell receptor; Notch ligand; Notch1; SIGNALING CONTROLS; T-CELLS; EXPRESSION; RECEPTOR; APOPTOSIS; MATURE; DIFFERENTIATION; GENERATION; SURVIVAL; FATE;

D O I：

10.1111/imm.12333

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The roles of Notch1 and Notch2 in T-cell function have been well studied, but the functional roles of Notch in B cells have not been extensively investigated, except for Notch2 involvement in peripheral marginal zone B-cell differentiation. This study examined the roles of Notch1 in murine primary B cells. During B-cell activation by B-cell receptor ligation, Notch1 was up-regulated while Notch2 was not. In addition, Notch1 up-regulation itself did not contribute to the further activation of B cells, but the Notch ligand was important for Notch1-mediated further B-cell activation. Moreover, Notch1 deficiency significantly decreased B-cell activation and antibody secretion under the presence of Notch ligand. These data suggest that Notch1 is an important mediator for enhancing B-cell activation and antibody secretion by Notch ligand.

引用

页码：550 / 559

页数：10

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