Molarless condition suppresses proliferation but not differentiation rates into neurons in the rat dentate gyrus

被引：17

作者：

Aoki, Hiromichi ^{[1
,2
]}

Kimoto, Katsuhiko ^{[1
,2
]}

Hori, Norio ^{[1
,2
]}

Hoshi, Noriyuki ^{[1
]}

Yamamoto, Toshiharu ^{[2
,3
]}

Onozuka, Minoru ^{[2
,4
]}

机构：

[1] Kanagawa Dent Coll, Dept Oral & Maxillofacial Rehabil, Div Fixed Prosthodont, Yokosuka, Kanagawa 2388580, Japan

[2] Kanagawa Dent Coll, Res Ctr Brain & Oral Sci, Yokosuka, Kanagawa 2388580, Japan

[3] Kanagawa Dent Coll, Dept Human Biol, Yokosuka, Kanagawa 2388580, Japan

[4] Kanagawa Dent Coll, Dept Physiol & Neurosci, Yokosuka, Kanagawa 2388580, Japan

来源：

NEUROSCIENCE LETTERS | 2010年 / 469卷 / 01期

关键词：

Molarless; Neurogenesis; Dentate gyrus; Hippocampus; Plasma corticosterone; AGED SAMP8 MICE; ADULT NEUROGENESIS; HIPPOCAMPAL NEUROGENESIS; CELL-PROLIFERATION; SPATIAL MEMORY; MOUSE; IMPAIRMENT; INCREASES; EXPOSURE; SYSTEM;

D O I：

10.1016/j.neulet.2009.11.041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The dentate gyrus (DG) of the hippocampal complex is one of the few areas of the rodent brain where neurogenesis continues throughout adulthood. We investigated the effects of the molarless condition on cell proliferation, rate of differentiation into neurons in the subgranular zone of the DG, and plasma corticosterone levels. The molarless condition decreased cell proliferation in the DG and increased plasma corticosterone levels. Approximately 80% of newly generated cells differentiated into neurons and the remaining 20% of the cells differentiated into astrocytes. These ratios were not significantly different between control and molarless rats. In conclusion, the rates of neurogenesis and gliogenesis in the DG are suppressed by the molarless condition, and this suppression might be associated with the increased corticosteroid levels in molarless subjects. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：44 / 48

页数：5