PTEN/mTOR and axon regeneration

被引：309

作者：

Park, Kevin K. ^{[1
]}

Liu, Kai

Hu, Yang

Kanter, Jennifer L.

He, Zhigang

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

来源：

EXPERIMENTAL NEUROLOGY | 2010年 / 223卷 / 01期

关键词：

Pten; mTOR; axon; regeneration; PNS; CNS; MEMBRANE EXPANSION; COMPARTMENTALIZED CULTURES; SYMPATHETIC NEURONS; LOCAL-CONTROL; GROWTH; MTOR; SURVIVAL; MECHANISMS; ROLES; CNS;

D O I：

10.1016/j.expneurol.2009.12.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

How axon regeneration is controlled in both PNS and CNS remains elusive. Mechanistic studies of axon growth during development and axon regeneration after injury reveal the PTEN dependent molecular mechanism as a commonality. This pathway could impact the processes occurring in the neuronal soma, such as mTOR-regulated protein translation, and in the axons, such as cytoskeleton assembly. In this review, we will discuss the current understanding of the involvement of these processes in the regulation of axon growth and the potential implication in promoting axon regeneration after injury. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：45 / 50

页数：6

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