Total synthesis of the salicylate enamide macrolide oximidine II

被引：104

作者：

Wang, X

Porco, JA

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

[2] Boston Univ, Ctr Chem Methodol, Boston, MA 02215 USA

[3] Boston Univ, Lib Dev, Boston, MA 02215 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 20期

关键词：

D O I：

10.1021/ja034030o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The asymmetric synthesis of the salicylate enamide macrolide oximidine II is reported. The synthesis involves a highly regio- and stereoselective ring-closing metathesis of a bis-diene substrate to construct the macrocyclic triene core. Copper(I)-mediated amidation of a (Z)-vinyl iodide was employed to attach the enamide side chain. Copyright © 2003 American Chemical Society.

引用

页码：6040 / 6041

页数：2

共 32 条

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