Parahippocampal gray matter density in panic disorder:: A voxel-based morphometric study

Objective: The authors examined possible cerebral gray matter abnormalities in patients with panic disorder. Method: Gray matter concentration in 18 panic disorder outpatients and 18 healthy subjects was compared by using a voxel-based morphometry approach. Results: Gray matter density of the left parahippocampal gyrus was significantly lower in patients with panic disorder compared with healthy subjects. Conclusions: This result provides further support for the involvement of the parahippocampal area in the pathophysiology of panic disorder.