Circadian rhythms and cancer

被引：115

作者：

Gery, Sigal ^{[1
]}

Koeffler, H. Phillip ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Div Hematol Oncol, Cedars Sinai Med Ctr, Los Angeles, CA 90024 USA

[2] Natl Univ Singapore, Singapore 117548, Singapore

来源：

CELL CYCLE | 2010年 / 9卷 / 06期

关键词：

circadian; hematopoietic system; breast cancer; prostate cancer; tumorigenesis; NIGHT-SHIFT WORK; CLOCK GENE-EXPRESSION; HUMAN BONE-MARROW; BREAST-CANCER; MYELOID-LEUKEMIA; PROSTATE-CANCER; ANDROGEN RECEPTOR; DOWN-REGULATION; RISK; PER2;

D O I：

10.4161/cc.9.6.11046

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The circadian clock is an endogenous time keeping system shared by most organisms. In mammals, a master pacemaker in the hypothalamus orchestrates temporal alignment of behavior and physiology by transmitting daily signals to multiple clocks in peripheral tissues. Disruption of this communication has a profound affect on human health and has been linked to diverse pathogenic conditions, including cancer. At the center of the molecular circadian machinery is a set of clock genes, generating rhythmic oscillations on a cellular level. In the past several years, research from different fields has revealed the complexity and ubiquitous nature of circadian regulation, uncovering intriguing associations between clock components and cellular pathways implicated in tumorigenesis. In this review, we discuss the emerging role of circadian genes in hematological and hormone-related malignances. These new insights suggest that manipulating circadian biology as a way to fight cancer, as well as, other life threatening diseases is within the realm of possibility.

引用

页码：1097 / 1103

页数：7

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