Nucleophilic catalysis by 4-(dialkylamino)pyridines revisited-the search for optimal reactivity and selectivity

被引：241

作者：

Spivey, AC ^{[1
]}

Arseniyadis, S ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 41期

基金：

英国工程与自然科学研究理事会;

关键词：

asymmetric catalysis; esterification N ligands; nucleophilic catalysis; organocatalysis;

D O I：

10.1002/anie.200460373

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A complex interplay between catalyst structure, acylating agent, auxiliary base, and solvent governs the reactivity and selectivity in 4-(dialkylamino) pyridine-catalyzed esterification reactions (see scheme). This highlight attempts a rationalization of the complicated mechanism and puts forward some explanations for seemingly contradictory experimental observations.

引用

页码：5436 / 5441

页数：6

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