Targeted gene delivery to cancer cells: Directed assembly of nanometric DNA particles coated with folic acid

被引：78

作者：

Zuber, G ^{[1
]}

Zammut-Italiano, L ^{[1
]}

Dauty, E ^{[1
]}

Behr, JP ^{[1
]}

机构：

[1] ULP Strasbourg, CNRS, Lab Chim Genet Associe, Fac Pharm, F-67401 Illkirch Graffenstaden, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 23期

关键词：

cell recognition; DNA binding; nanostructures; supramolecular chemistry; transfection;

D O I：

10.1002/anie.200250446

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthetic viruslike particle: Monomolecular condensation of a gene into a 30-nm particle was performed by the DNA-templated air oxidation of a cationic thiol detergent to a gemini lipid (depicted in yellow). A folic acid coating was added (in the form of the DNA-binding folate-containing compounds represented schematically by 2) and the resulting DNA particles 1 were shown to be nanometric and stable, and to enter cells through the folic acid receptor.

引用

页码：2666 / 2669

页数：4

共 21 条

[1] DEMONSTRATION OF NUCLEAR COMPARTMENTALIZATION OF GLUTATHIONE IN HEPATOCYTES [J].

BELLOMO, G ;

VAIRETTI, M ;

STIVALA, L ;

MIRABELLI, F ;

RICHELMI, P ;

ORRENIUS, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4412-4416

[2] A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].

BOUSSIF, O ;

LEZOUALCH, F ;

ZANTA, MA ;

MERGNY, MD ;

SCHERMAN, D ;

DEMENEIX, B ;

BEHR, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301

[3] A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA [J].

Brandén, LJ ;

Mohamed, AJ ;

Smith, CIE .

NATURE BIOTECHNOLOGY, 1999, 17 (08) :784-787

[4] Folate receptor-α is a cofactor for cellular entry by Marburg and Ebola viruses [J].

Chan, SY ;

Empig, CJ ;

Welte, FJ ;

Speck, RF ;

Schmaljohn, A ;

Kreisberg, JF ;

Goldsmith, MA .

CELL, 2001, 106 (01) :117-126

[5] Dimerizable cationic detergents with a low cmc condense plasmid DNA into nanometric particles and transfect cells in culture [J].

Dauty, E ;

Remy, JS ;

Blessing, T ;

Behr, JP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (38) :9227-9234

[6] Tumor regression by targeted gene delivery to the neovasculature [J].

Hood, JD ;

Bednarski, M ;

Frausto, R ;

Guccione, S ;

Reisfeld, RA ;

Xiang, R ;

Cheresh, DA .

SCIENCE, 2002, 296 (5577) :2404-2407

[7] Hurdles and hopes for cancer treatment [J].

Hunt, KK ;

Vorburger, SA .

SCIENCE, 2002, 297 (5580) :415-416

[8]

LabatMoleur F, 1996, GENE THER, V3, P1010

[9] Targeting tumors with non-viral gene delivery systems [J].

Ogris, M ;

Wagner, E .

DRUG DISCOVERY TODAY, 2002, 7 (08) :479-485

[10] Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER [J].

Pelkmans, L ;

Kartenbeck, J ;

Helenius, A .

NATURE CELL BIOLOGY, 2001, 3 (05) :473-483

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