Targeted gene delivery to cancer cells: Directed assembly of nanometric DNA particles coated with folic acid

被引：78

作者：

Zuber, G ^{[1
]}

Zammut-Italiano, L ^{[1
]}

Dauty, E ^{[1
]}

Behr, JP ^{[1
]}

机构：

[1] ULP Strasbourg, CNRS, Lab Chim Genet Associe, Fac Pharm, F-67401 Illkirch Graffenstaden, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 23期

关键词：

cell recognition; DNA binding; nanostructures; supramolecular chemistry; transfection;

D O I：

10.1002/anie.200250446

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthetic viruslike particle: Monomolecular condensation of a gene into a 30-nm particle was performed by the DNA-templated air oxidation of a cationic thiol detergent to a gemini lipid (depicted in yellow). A folic acid coating was added (in the form of the DNA-binding folate-containing compounds represented schematically by 2) and the resulting DNA particles 1 were shown to be nanometric and stable, and to enter cells through the folic acid receptor.

引用

页码：2666 / 2669

页数：4

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