Multiple myeloma: Evolving genetic events and host interactions

被引：631

作者：

Kuehl, WM

Bergsagel, PL

机构：

[1] Bethesda Naval Hosp, Genet Branch, Ctr Canc Res, NCI,NIH, Bethesda, MD 20889 USA

[2] Cornell Univ, Weill Med Coll, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 03期

关键词：

D O I：

10.1038/nrc746

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What causes full-blown myeloma? And can our molecular understanding of this common haematological malignancy be used to develop effective preventive and treatment strategies?

引用

页码：175 / 187

页数：13

共 165 条

[81] The retinoblastoma susceptibility gene RB-1 in multiple myeloma [J].

JugeMorineau, N ;

Harousseau, JL ;

Amiot, M ;

Bataille, R .

LEUKEMIA & LYMPHOMA, 1997, 24 (3-4) :229-237

[82] A TRANSCRIPTIONAL REPRESSOR OF C-MYC [J].

KAKKIS, E ;

RIGGS, KJ ;

GILLESPIE, W ;

CALAME, K .

NATURE, 1989, 339 (6227) :718-721

[83] Current status of clinical trials of farnesyltransferase inhibitors [J].

Karp, JE ;

Kaufmann, SH ;

Adjei, AA ;

Lancet, JE ;

Wright, JJ ;

End, DW .

CURRENT OPINION IN ONCOLOGY, 2001, 13 (06) :470-476

[84]

Kipps T J, 2000, Hematol Cell Ther, V42, P5, DOI 10.1007/s00282-000-0005-4

[85]

Klein B, 1998, Curr Opin Hematol, V5, P186, DOI 10.1097/00062752-199805000-00007

[86] INTERLEUKIN-6 IN HUMAN MULTIPLE-MYELOMA [J].

KLEIN, B ;

ZHANG, XG ;

LU, ZY ;

BATAILLE, R .

BLOOD, 1995, 85 (04) :863-872

[87]

KLUCHI N, 1999, J EXP MED, V189, P63

[88] Deletions of chromosome 13q in monoclonal gammopathy of undetermined significance [J].

Königsberg, R ;

Ackermann, J ;

Kaufmann, H ;

Zojer, N ;

Urbauer, E ;

Krömer, E ;

Jäger, U ;

Gisslinger, H ;

Schreiber, S ;

Heinz, R ;

Ludwig, H ;

Huber, H ;

Drach, J .

LEUKEMIA, 2000, 14 (11) :1975-1979

[89]

Küppers R, 1999, NEW ENGL J MED, V341, P1520

[90] Mechanisms of chromosomal translocations in B cell lymphomas [J].

Küppers, R ;

Dalla-Favera, R .

ONCOGENE, 2001, 20 (40) :5580-5594

← 4 5 6 7 8 9 10 11 12 13 →