Pd0-catalyzed three-component tandem double-addition-cyclization reaction:: Stereoselective synthesis of cis-pyrrolidine derivatives

被引：47

作者：

Ma, SM ^{[1
]}

Jiao, N ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 24期

关键词：

D O I：

10.1002/anie.200290033

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cis-2,5-Disubstituted pyrrolidine skeletons have been constructed by the Pd0- catalyzed three-component tandem double-addition-cyclization reaction of 2-(2,3-butadienyl)malonates, organohalides, and imines (see scheme, yields: 81-100%; cis/trans > 95:5).

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页码：4737 / 4740

页数：4

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