Pharmacological proteasome inhibitors and their therapeutic potential

被引：29

作者：

Dou, QP ^{[1
]}

Nam, S ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Drug Discovery Program, Tampa, FL 33612 USA

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2000年 / 10卷 / 08期

关键词：

Alzheimer's disease; autoimmune disease; bone disease; cancer; inflammation; muscle wasting disease; neurological disease; Parkinson's disease;

D O I：

10.1517/13543776.10.8.1263

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Implication of the proreasome in human cancer, inflammation, autoimmune and other diseases has prompted design, synthesis and evaluation of various pharmacological proteasome inhibitors. In this review, we will summarise the literature related to human cancer cell death induction by proteasome inhibitors, examine the proteasome inhibitor patents published over the past five years and evaluate the potential clinical applications in the use of proteasome inhibitors for treating cancer and other human diseases.

引用

页码：1263 / 1272

页数：10

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