Neuroprotection against hypoxia-ischemia in neonatal rat brain by novel superoxide dismutase mimetics

被引：26

作者：

Shimizu, K

Rajapakse, N

Horiguchi, T

Payne, RM

Busija, DW

机构：

[1] Wake Forest Univ, Sch Med, Dept Physiol, Winston Salem, NC 27157 USA

[2] Wake Forest Univ, Sch Med, Dept Pharmacol, Winston Salem, NC 27157 USA

[3] Wake Forest Univ, Sch Med, Program Mol Med, Winston Salem, NC 27157 USA

[4] Wake Forest Univ, Sch Med, Dept Pediat, Winston Salem, NC 27157 USA

来源：

NEUROSCIENCE LETTERS | 2003年 / 346卷 / 1-2期

关键词：

superoxide anion; brain injury; reactive oxygen species; neonate;

D O I：

10.1016/S0304-3940(03)00558-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the effects of two new low molecular weight nonpeptidyl superoxide dismutase (SOD) mimetics (M40403/M40401; MetaPhore Pharmaceuticals) on infarct volume after hypoxia-ischemia injury (H/I) in immature rats. Animals received vehicle or different doses of M40403 or M40401 i.p. 2 It before exposure to 3 It of 8% hypoxia. The infarct volume of the hemisphere ipsilateral to carotid ligation 24 h later was 73.9 +/- 8.9% in vehicle animals (n = 9), and decreased to 39.7 +/- 7.2% (P < 0.05, n = 10) in animals treated with 3 mg/kg M40403 and to 37.2 +/- 6.4% for animals receiving 3 mg/kg M40401 (P < 0.05, n = 8). These data indicate that the SOD mimetics M40403 and M40401 have protective effects against hypoxic-ischemic brain injury, and suggest the involvement of superoxide anion in neuronal cell injury during H/I. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：41 / 44

页数：4

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