Biochemical Markers of Joint Tissue Turnover

被引：20

作者：

Bay-Jensen, Anne-Christine ^{[1
]}

Sondergaard, Bodil Cecilie ^{[1
]}

Christiansen, Claus ^{[1
]}

Karsdal, Morten A. ^{[1
]}

Madsen, Suzi Hogh ^{[1
]}

Qvist, Per ^{[1
]}

机构：

[1] Nord Biosci AS, Herlev, Denmark

来源：

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES | 2010年 / 8卷 / 01期

关键词：

AMINO-TERMINAL PROPEPTIDE; OSTEOARTHRITIS STRUCTURAL ARTHRITIS; GENERATED AGGRECAN FRAGMENTS; HUMAN ARTICULAR-CARTILAGE; II COLLAGEN; KNEE OSTEOARTHRITIS; RHEUMATOID-ARTHRITIS; SYNOVIAL-FLUID; DISEASE PROGRESSION; HIP OSTEOARTHRITIS;

D O I：

10.1089/adt.2009.0199

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Recent disappointments in late stage developments of anti-osteoarthritic drugs have reinforced efforts to develop better biomarkers for application in both the drug development process as well as in the routine management of these patients. Here we provide a brief review of biochemical tests available for the study of tissue turnover in each of the three compartments of the articular joint, that is the bone, the cartilage, and the synovium. Finally, we provide some perspective to future developments in biomarker discovery and discuss the potential impact such technologies could have on the drug development process.

引用

页码：118 / 124

页数：7

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