Diffuse scleroderma occurring after the use of paclitaxel for ovarian cancer

被引：31

作者：

De Angelis, R ^{[1
]}

Bugatti, L ^{[1
]}

Cerioni, A ^{[1
]}

Del Medico, P ^{[1
]}

Filosa, G ^{[1
]}

机构：

[1] Osped Augusto Murri, Dept Radiol, I-60035 Ancona, Italy

来源：

CLINICAL RHEUMATOLOGY | 2003年 / 22卷 / 01期

关键词：

chemotherapy; drug side effects; scleroderma;

D O I：

10.1007/s10067-002-0635-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A case of diffuse scleroderma in a 56-year-old woman who received paclitaxel for the treatment of a metastatic ovarian cancer is presented. The clinical cutaneous alterations, as well as the capillaroscopic and histological findings, were indistinguishable from those encountered in definite systemic sclerosis (SSc). In contrast to SSc, Raynaud's phenomenon and cutaneous calcinosis were absent and antinuclear antibodies were negative. The temporal relationship between the onset of skin involvement and administration of the drug may indicate an effect of paclitaxel.

引用

页码：49 / 52

页数：4

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