The ETO (MTG8) gene family

被引：132

作者：

Davis, JN

McGhee, L

Meyers, S

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol F7 26, Shreveport, LA 71130 USA

[2] Feist Weiller Canc Ctr, Shreveport, LA 71130 USA

来源：

GENE | 2003年 / 303卷

关键词：

leukemia; co-repressor; AML-1/ETO; transcription;

D O I：

10.1016/S0378-1119(02)01172-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cloning and characterization of the 8;21 chromosomal breakpoint identified AML1 on chromosome 21 and ETO (MTG8) on chromosome 8, and the resultant chimeric gene product, AML-1/ETO. The ETO gene family now includes three human members encoding proteins composed of four evolutionarily conserved domains termed nervy homology regions (NHR) 1-4. ETO associates with N-CoR/Sin3a/HDAC complexes in vivo and acts as a corepressor for the promyelocytic zinc finger protein. Moreover, ETO is nuclear matrix attached at sites coincident with histone deacetylase enzymes and mSin3a. These data suggest that ETO proteins function as transcriptional corepressors. This review focuses on the ETO gene family in terms of expression and function. Specifically, the role of ETO as a co-repressor will be detailed. Additionally, the impact of this recent discovery on treatment of t(8;21)-containing leukemia will be discussed. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 10

页数：10

共 66 条

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