Genotoxicity study of reaction products of sorbic acid

被引：17

作者：

Ferrand, C

Marc, F

Fritsch, P

Cassand, P

Blanquat, GD

机构：

[1] Univ Bordeaux 1, Dept Univ Sci Agen, Lab Anal Valeur Biol Aliments, F-47000 Agen, France

[2] Univ Bordeaux 1, ISTAB, Lab Toxicol Alimentaire, F-33405 Talence, France

[3] Univ Toulouse 3, CHU Rangueil, INSERM, Lab UPS,EA 2405, F-31054 Toulouse, France

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2000年 / 48卷 / 08期

关键词：

3D test; amines; reaction products; Salmonella typhimurium; sorbic acid;

D O I：

10.1021/jf990777f

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Sorbic acid (E200) and its salts (potassium and calcium sorbate: E202 and E203) are allowed for use as preservatives in numerous processed foods. Sorbic acid has a conjugated system of double bonds which makes it susceptible to nucleophilic attack, sometimes giving mutagenic products. Under conditions typical of food processing (50-80 degrees C), we analyzed the cyclic derivatives resulting from a double addition reaction between sorbic acid and various:amines. Mutagenesis studies, involving the Ames test and genotoxicity studies with HeLa cells and plasmid DNA, showed that none of the products studied presented either mutagenic or genotoxic activities.

引用

页码：3605 / 3610

页数：6

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