Thrombin-induced platelet microbicidal protein susceptibility phenotype influences the outcome of oxacillin prophylaxis and therapy of experimental Staphylococcus aureus endocarditis

被引：19

作者：

Dhawan, VK

Bayer, AS

Yeaman, MR

机构：

[1] Charles R Drew Univ Med & Sci, Martin Luther King Med Ctr, Div Infect Dis, Los Angeles, CA 90059 USA

[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Harbor Med Ctr, Div Adult Infect Dis, Torrance, CA 90509 USA

[4] Univ Calif Los Angeles, Harbor Med Ctr, St Johns Cardiovasc Res Ctr, Torrance, CA 90509 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 11期

关键词：

D O I：

10.1128/AAC.44.11.3206-3209.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We previously showed that in vitro susceptibility profiles of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 (tPMP-1) impacted the outcome of vancomycin treatment in experimental infective endocarditis. In this same model, treatment with oxacillin (a more rapid staphylocidal agent than vancomycin) enhanced the clearance of both tPMP-1-susceptible and -resistant cells from vegetations. The extent of clearance was greater for tPMP-1-susceptible cells.

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页码：3206 / 3209

页数：4

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