Novel functions for 'nuclear factors' in the cytoplasm: The Sex-lethal paradigm

被引：10

作者：

Gebauer, F ^{[1
]}

Merendino, L ^{[1
]}

Hentze, MW ^{[1
]}

Valcarcel, J ^{[1
]}

机构：

[1] European Mol Biol Lab, Gene Express Program, D-69117 Heidelberg, Germany

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1997年 / 8卷 / 06期

关键词：

Sex-lethal; splicing; translational control; sex determination; dosage compensation;

D O I：

10.1006/scdb.1997.0181

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In recent years, novel functions for a number of nuclear factors have been uncovered in the cytoplasm, mainly at the level of translation. These factors behave as multifunctional regulators of gene expression and many play key roles in cell differentiation and development. One of the best characterized examples is that of Sex-lethal (SXL) an RNA-binding protein that is expressed in female Drosophila flies and controls sex determination and dosage compensation. Recent findings indicate that SXL, a paradigmatic regulator of splicing also controls translation of target mRNAs. This review attempts to summarize this evidence and provide an overview of 'nuclear factors' with roles in translation. (C) 1997 Academic Press Ltd.

引用

页码：561 / 566

页数：6

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