Higher-order Genome Organization in Human Disease

被引：145

作者：

Misteli, Tom ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 08期

关键词：

DOUBLE-STRAND BREAKS; NUCLEAR ARCHITECTURE; GENE-EXPRESSION; CHROMOSOME TERRITORIES; NIPPED-B; HETEROCHROMATIN PROTEIN-1; HUMAN HOMOLOG; CTCF BINDING; DNA-REPAIR; HISTONE H4;

D O I：

10.1101/cshperspect.a000794

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genomes are organized into complex higher-order structures by folding of the DNA into chromatin fibers, chromosome domains, and ultimately chromosomes. The higher-order organization of genomes is functionally important for gene regulation and control of gene expression programs. Defects in how chromatin is globally organized are relevant for physiological and pathological processes. Mutations and transcriptional misregulation of several global genome organizers are linked to human diseases and global alterations in chromatin structure are emerging as key players in maintenance of genome stability, aging, and the formation of cancer translocations.

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页数：17

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