Mitochondria at the heart of the cytotoxic attack

被引：14

作者：

Roberts, DL ^{[1
]}

Goping, IS ^{[1
]}

Bleackley, RC ^{[1
]}

机构：

[1] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 304卷 / 03期

基金：

加拿大健康研究院;

关键词：

granzyme; cytotoxic T lymphocyte; apoptosis; mitochondria;

D O I：

10.1016/S0006-291X(03)00624-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Granzyme B is a serine proteinase that acts as a key effector of cell death mediated by cytotoxic T lymphocytes. The enzyme is transferred from the cytotoxic cell to the pathogenic target cell where it cleaves and activates a number of substrates involved in the induction of apoptosis. However, recent evidence implicates mitochondria as playing an important role in both the initiation of apoptosis and control of substrate cleavage by granzyme B in cytotoxic T lymphocyte induced death. This review focuses on current research in this rapidly expanding field, specifically the role of mitochondria in cell death induced by components of cytotoxic granules in particular granzyme B. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：513 / 518

页数：6

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