Antiangiogenic therapy for primary and metastatic brain tumors

被引：18

作者：

Purow, B ^{[1
]}

Fine, HA ^{[1
]}

机构：

[1] NINDS, Neuro Oncol Branch, NCI, NIH, Bethesda, MD 20892 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2004年 / 18卷 / 05期

关键词：

D O I：

10.1016/j.hoc.2004.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We first provide the theoretic foundation of antiangiogenic therapy by describing the biology of angiogenesis as it applies to brain tumors. We then outline experimental antiangiogenic therapies that are being applied preclinically to brain tumors, as well as published clinical trial data and ongoing clinical trials in patients. Primary and metastatic brain tumors are covered, although there is far less exploration in the literature of brain metastases.

引用

页码：1161 / +

页数：22

共 139 条

[1] Squalamine, a novel cationic steroid, specifically inhibits the brush-border Na+/H+ exchanger isoform NHE3 [J].

Akhter, S ;

Nath, SK ;

Tse, CM ;

Williams, J ;

Zasloff, M ;

Donowitz, M .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1999, 276 (01) :C136-C144

[2]

Anderson SA, 2000, MAGNET RESON MED, V44, P433, DOI 10.1002/1522-2594(200009)44:3<433::AID-MRM14>3.0.CO

[3]

2-9

[4]

*ANG FDN, 2002, PHAS 2 END TRIAL BEG

[5] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[6] Steps toward mapping the human vasculature by phage display [J].

Arap, W ;

Kolonin, MG ;

Trepel, M ;

Lahdenranta, J ;

Cardó-Vila, M ;

Giordano, RJ ;

Mintz, PJ ;

Ardelt, PU ;

Yao, VJ ;

Vidal, CI ;

Chen, L ;

Flamm, A ;

Valtanen, H ;

Weavind, LM ;

Hicks, ME ;

Pollock, RE ;

Botz, GH ;

Bucana, CD ;

Koivunen, E ;

Cahill, D ;

Troncoso, P ;

Baggerly, KA ;

Pentz, RD ;

Do, KA ;

Logothetis, CJ ;

Pasqualini, R .

NATURE MEDICINE, 2002, 8 (02) :121-127

[7] Principles of treatment of malignant gliomas in adults: An overview [J].

Azizi, SA ;

Miyamoto, C .

JOURNAL OF NEUROVIROLOGY, 1998, 4 (02) :204-216

[8] Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival [J].

Batra, S ;

Perelman, N ;

Luck, LR ;

Shimada, H ;

Malik, P .

LABORATORY INVESTIGATION, 2003, 83 (10) :1477-1487

[9]

Bauer KS, 1999, CLIN CANCER RES, V5, P2324

[10] αvβ3 and αvβ5 integrin expression in glioma periphery [J].

Bello, L ;

Francolini, M ;

Marthyn, P ;

Zhang, JP ;

Carroll, RS ;

Nikas, DC ;

Strasser, JF ;

Villani, R ;

Cheresh, DA ;

Black, PM .

NEUROSURGERY, 2001, 49 (02) :380-389

← 1 2 3 4 5 6 7 8 9 10 →