Inhibitory cerebello-olivary projections and blocking effect in classical conditioning

被引：158

作者：

Kim, JJ ^{[1
]}

Krupa, DJ ^{[1
]}

Thompson, RF ^{[1
]}

机构：

[1] Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA

来源：

SCIENCE | 1998年 / 279卷 / 5350期

关键词：

D O I：

10.1126/science.279.5350.570

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The behavioral phenomenon of blocking indicates that the informational relationship between the conditioned stimulus and the unconditioned stimulus is essential in classical conditioning. The eyeblink conditioning paradigm is used to describe a neural mechanism that mediates blocking, Disrupting inhibition of the inferior olive, a structure that conveys unconditioned stimulus information (airpuff) to the cerebellum prevented blocking in rabbits. Recordings of cerebellar neuronal activity show that the inferior olive input to the cerebellum becomes suppressed as learning occurs. These results suggest that the inferior olive becomes functionally inhibited by the cerebellum during conditioning, and that this negative feedback process might be the neural mechanism mediating blocking.

引用

页码：570 / 573

页数：4

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