Synthesis and intramolecular cyclization of novel β,β-bis-(benzo[b]thienyl)dehydroalanine derivatives

被引：27

作者：

Abreu, AS ^{[1
]}

Silva, NO ^{[1
]}

Ferreira, PMT ^{[1
]}

Queiroz, MJRP ^{[1
]}

机构：

[1] Univ Minho, Dept Quim, P-4710057 Braga, Portugal

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 16期

关键词：

beta; beta-dibromodehydroalanine; beta-bis-(benzo[b]thienyl)dehydroalanine; Suzuki cross coupling; pyrrole derivatives;

D O I：

10.1016/S0040-4039(03)00564-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The methyl ester of tert-butyloxycarbonyl-beta,beta-dibromodehydroalanine was obtained in a one-pot procedure from bis-(N-tent-butyloxycarbonyl)dehydroalanine. The former was reacted with several boronic benzo[b]thiophene acids under Suzuki cross coupling conditions, to give new beta,beta-bis-(benzo[b]thienyl)dehydroalanines in high yields. These compounds were cyclized to pyrrole derivatives by treatment with Pd(OAc)(2) and Cu(OAc)(2) in DMF. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3377 / 3379

页数：3

共 5 条

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