Synthesis of novel β-substituted α,β-dehydroamino acid derivatives

被引：25

作者：

Ferreira, PMT ^{[1
]}

Maia, HLS ^{[1
]}

Monteiro, LS ^{[1
]}

Sacramento, J ^{[1
]}

机构：

[1] Univ Minho, Dept Chem, P-4700320 Braga, Portugal

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 39期

关键词：

alpha; beta-dehydroamino acids; beta-substituted alanines; beta-substituted alpha;

D O I：

10.1016/S0040-4039(00)01271-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Substituted alpha,beta-dehydroamino acids are synthesised in high yields by a Michael addition of heterocyclic nucleophiles to the methyl esters of N-tert-butyloxycarbonyl,N-(4-toluenesulfonyl)dehydroamino acids, followed by a base-induced elimination of the 4-toluenesulfonyl group with regeneration of the alpha,beta-double bond. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：7437 / 7441

页数：5

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