Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp Tu 6368 -: I.: Taxonomy, fermentation, isolation and biological activities

被引：36

作者：

Antal, N

Fiedler, HP

Stackebrandt, E

Beil, W

Ströch, K

Zeeck, A

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] DSMZ GmbH, D-38124 Braunschweig, Germany

[3] Hannover Med Sch, Inst Pharmacol, D-30625 Hannover, Germany

[4] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 02期

关键词：

new substance; antitumor; screening; taxonomy; fermentation; isolation;

D O I：

10.1038/ja.2005.12

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new xanthone compound named retymicin (1) was isolated together with galtamycin B (2) and saquayamycin Z (3), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(alpha-ribofuranosyl)-lumichrome (4) from Micromonospora strain Tu 6368, isolated from a soil sample collected in Romania. Retymicin, galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria.

引用

页码：95 / 102

页数：8

共 29 条

[1]

[Anonymous], 1993, NAT PROD LETT

[2]

[Anonymous], 1990, IDENTIFICATION BACTE

[3]

Bode HB, 2002, CHEMBIOCHEM, V3, P619, DOI 10.1002/1439-7633(20020703)3:7<619::AID-CBIC619>3.0.CO

[4]

2-9

[5] DISTRIBUTION OF MENAQUINONES IN ACTINOMYCETES AND CORYNEBACTERIA [J].

COLLINS, MD ;

PIROUZ, T ;

GOODFELLOW, M ;

MINNIKIN, DE .

JOURNAL OF GENERAL MICROBIOLOGY, 1977, 100 (JUN) :221-230

[6] THE CHEMICAL COMPOSITION OF THE CELL WALL IN SOME GRAM-POSITIVE BACTERIA AND ITS POSSIBLE VALUE AS A TAXONOMIC CHARACTER [J].

CUMMINS, CS ;

HARRIS, H .

JOURNAL OF GENERAL MICROBIOLOGY, 1956, 14 (03) :583-600

[7] THE SORAPHENS - A FAMILY OF NOVEL ANTIFUNGAL COMPOUNDS FROM SORANGIUM-CELLULOSUM (MYXOBACTERIA) .1. SORAPHEN A(1-ALPHA) - FERMENTATION, ISOLATION, BIOLOGICAL PROPERTIES [J].

GERTH, K ;

BEDORF, N ;

IRSCHIK, H ;

HOFLE, G ;

REICHENBACH, H .

JOURNAL OF ANTIBIOTICS, 1994, 47 (01) :23-31

[8]

GREVER MR, 1992, SEMIN ONCOL, V19, P622

[9] Agrococcus jenensis gen nov, sp nov, a new genus of actinomycetes with diaminobutyric acid in the cell wall [J].

Groth, I ;

Schumann, P ;

Weiss, N ;

Martin, K ;

Rainey, FA .

INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1996, 46 (01) :234-239

[10]

HORNER T, 1989, APPL MICROBIOL BIOT, V30, P219

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