GABAA receptors:: Properties and trafficking

被引：82

作者：

Michels, Guido

Moss, Stephen J.

机构：

[1] Univ Penn, Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA

[2] UCL, London WC1E 6BT, England

[3] Univ Cologne, D-5000 Cologne 41, Germany

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2007年 / 42卷 / 01期

基金：

英国惠康基金;

关键词：

gamma-aminobutyric acid; benzodiazepines; ligand-gated ion channels; clathrin; gephyrin; GABARAP; Plic-1; endocytosis;

D O I：

10.1080/10409230601146219

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fast synaptic inhibition in the brain and spinal cord is mediated largely by ionotropic gamma-aminobutyric acid (GABA) receptors. GABA(A) receptors play a key role in controlling neuronal activity; thus modulating their function will have important consequences for neuronal excitation. GABAA receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are involved in a number of CNS diseases, including sleep disturbances, anxiety, premenstrual syndrome, alcoholism, muscle spasms, Alzheimer's disease, chronic pain, schizophrenia, bipolar affective disorders, and epilepsy. This review focuses on the functional and pharmacological properties of GABA(A) receptors and trafficking as an essential mechanism underlying the dynamic regulation of synaptic strength.

引用

页码：3 / 14

页数：12

共 94 条

[41] Association of GRIP1 with a GABAA receptor associated protein suggests a role for GRIP1 at inhibitory synapses [J].