Metformin for the treatment of polycystic ovary syndrome

被引:58
作者
Barbieri, RL [1 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA
关键词
D O I
10.1016/S0029-7844(03)00045-0
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: To familiarize obstetrician-gynecologists with the use of metformin for the treatment of polycystic ovary syndrome (PCOS). DATA SOURCES: Using OVID, 94 English-language articles published after 1966 indexed with the key words "metformin" and "polycystic ovary syndrome" were identified. METHODS OF STUDY SELECTION: Studies were excluded if they did not have a control group, did not use the National Institutes of Health definition of PCOS, did not have a clinical outcome as an end point, and were not in the English language. Reviews were also excluded, leaving 21 articles for inclusion. TABULATION, INTEGRATION, AND RESULTS: Three clinical trials reported that for the treatment of anovulatory infertility caused by PCOS, metformin plus clomiphene is more effective than domiphene alone in inducing ovulation. For the treatment of irregular menses caused by PCOS in women not attempting conception, metformin therapy may restore ovulatory menses in the majority of women. However, most women will require 4-6 months of metformin therapy before they achieve ovulatory menses. In obese women, metformin plus a low-calorie diet may be associated with more weight loss than a low-calorie diet alone. CONCLUSION: Polycystic ovary syndrome is a common gynecologic endocrine disorder. Obstetrician-gynecologists should be familiar with the indications and contraindications for the use of metformin in their practice.
引用
收藏
页码:785 / 793
页数:9
相关论文
共 72 条
[41]   Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome [J].
Kocak, M ;
Caliskan, E ;
Simsir, C ;
Haberal, A .
FERTILITY AND STERILITY, 2002, 77 (01) :101-106
[42]   ROLE OF METFORMIN ACCUMULATION IN METFORMIN-ASSOCIATED LACTIC-ACIDOSIS [J].
LALAU, JD ;
LACROIX, C ;
COMPAGNON, P ;
DECAGNY, B ;
RIGAUD, JP ;
BLEICHNER, G ;
CHAUVEAU, P ;
DULBECCO, P ;
GUERIN, C ;
HAEGY, JM ;
LOIRAT, P ;
MARCHAND, B ;
RAVAUD, Y ;
WEYNE, P ;
FOURNIER, A .
DIABETES CARE, 1995, 18 (06) :779-784
[43]   A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome [J].
Legro, RS ;
Finegood, D ;
Dunaif, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (08) :2694-2698
[44]   Repeatability characteristics of simple indices of insulin resistance: Implications for research applications [J].
Mather, KJ ;
Hunt, AE ;
Steinberg, HO ;
Paradisi, G ;
Hook, G ;
Katz, A ;
Quon, MJ ;
Baron, AD .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (11) :5457-5464
[45]   Metformin and contrast media - A dangerous combination? [J].
McCartney, MM ;
Gilbert, FJ ;
Murchison, LE ;
Pearson, D ;
McHardy, K ;
Murray, AD .
CLINICAL RADIOLOGY, 1999, 54 (01) :29-33
[46]   Insulin resistance and cardiovascular disease [J].
McFarlane, SI ;
Banerji, M ;
Sowers, JR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (02) :713-718
[47]   Lactic acidosis in patients with diabetes treated with metformin [J].
Misbin, RI ;
Green, L ;
Stadel, BV ;
Gueriguian, JL ;
Gubbi, A ;
Fleming, GA .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (04) :265-266
[48]   Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: A randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation [J].
Moghetti, P ;
Castello, R ;
Negri, C ;
Tosi, F ;
Perrone, F ;
Caputo, M ;
Zanolin, E ;
Muggeo, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (01) :139-146
[49]   Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome [J].
Morin-Papunen, LC ;
Koivunen, RM ;
Ruokonen, A ;
Martikainen, HK .
FERTILITY AND STERILITY, 1998, 69 (04) :691-696
[50]  
MOROS SK, 2001, EUR RADIOL, V11, P1267