Development of the prenatal cutaneous antigen-presenting cell network

被引：13

作者：

Elbe-Buerger, Adelheid ^{[1
]}

Schuster, Christopher ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Dermatol, Div Immunol Allergy & Infect Dis, Vienna Competence Ctr, A-1090 Vienna, Austria

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2010年 / 88卷 / 04期

基金：

奥地利科学基金会;

关键词：

skin; human; fetal; embryonic; antigen-presenting cell; Langerhans cell; EPIDERMAL LANGERHANS CELLS; DERMAL DENDRITIC CELLS; REGULATORY T-CELLS; ALLERGIC CONTACT-DERMATITIS; HUMAN PERIPHERAL-BLOOD; DRAINING LYMPH-NODES; BONE-MARROW; HUMAN-SKIN; FETAL SKIN; IN-UTERO;

D O I：

10.1038/icb.2010.13

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The skin, and in particular the epidermis, is a physical barrier that protects the body from external threats and is critically involved in immune reactivity. Professional antigen-presenting cells, such as epidermal Langerhans cells and dermal dendritic cells, are gaining prominence as principal players orchestrating the decision between immunity and tolerance. A focus of research interest in recent years has been the investigation of these cells in mammalian prenatal skin. In this review, we will compare the recent progress in dissecting the phenotype and functional role of antigen-presenting cells in the developing human and mouse skin before birth and perinatally, and will discuss how this knowledge improves our understanding of the level of immunocompetence of the skin in utero. Immunology and Cell Biology (2010) 88, 393-399; doi: 10.1038/icb.2010.13; published online 9 March 2010

引用

页码：393 / 399

页数：7

共 104 条

[21] Role of graft interleukin-10 expression in the tolerogenicity of neonatal skin allografts [J].

De Fazio, SR ;

Gozzo, JJ .

TRANSPLANTATION, 2000, 70 (09) :1371-1377

[22]

Demangel C, 2002, EUR J IMMUNOL, V32, P994, DOI 10.1002/1521-4141(200204)32:4<994::AID-IMMU994>3.3.CO

[23]

2-Y

[24] Acquisition of immune function during the development of the Langerhans cell network in neonatal mice [J].

Dewar, AL ;

Doherty, KV ;

Woods, GM ;

Lyons, AB ;

Muller, HK .

IMMUNOLOGY, 2001, 103 (01) :61-69

[25] Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis [J].

Ding, WH ;

Beissert, S ;

Deng, L ;

Miranda, E ;

Cassetty, C ;

Seiffert, K ;

Campton, KL ;

Yan, ZM ;

Murphy, GF ;

Bluestone, JA ;

Granstein, RD .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (12) :1923-1931

[26]

Drijkoningen M, 1987, Pediatr Dermatol, V4, P11, DOI 10.1111/j.1525-1470.1987.tb00745.x

[27]

ELBE A, 1989, J IMMUNOL, V143, P2431

[28] EARLY MOLECULAR EVENTS IN THE INDUCTION-PHASE OF CONTACT SENSITIVITY [J].

ENK, AH ;

KATZ, SI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (04) :1398-1402

[29] Human Langerhans cells express a specific TLR profile and differentially respond to viruses and Gram-positive bacteria [J].

Flacher, Vincent ;

Bouschbacher, Marielle ;

Verronese, Estelle ;

Massacrier, Catherine ;

Sisirak, Vanja ;

Berthier-Vergnes, Odile ;

de Saint-Vis, Blandine ;

Caux, Christophe ;

Dezutter-Dambuyant, Colette ;

Lebecque, Serge ;

Valladeau, Jenny .

JOURNAL OF IMMUNOLOGY, 2006, 177 (11) :7959-7967

[30] ONTOGENY OF LANGERHANS CELLS IN HUMAN-EMBRYONIC AND FETAL SKIN - CELL DENSITIES AND PHENOTYPIC-EXPRESSION RELATIVE TO EPIDERMAL GROWTH [J].

FOSTER, CA ;

HOLBROOK, KA .

AMERICAN JOURNAL OF ANATOMY, 1989, 184 (02) :157-164

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