Toll-like receptors in the induction of the innate immune response

被引：2508

作者：

Aderem, A ^{[1
]}

Ulevitch, RJ

机构：

[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

NATURE | 2000年 / 406卷 / 6797期

关键词：

D O I：

10.1038/35021228

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.

引用

页码：782 / 787

页数：6

共 59 条

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