Room Temperature Direct Alkynylation of 1,3,4-Oxadiazoles with Alkynyl Bromides under Copper Catalysis

被引：89

作者：

Kawano, Tsuyoshi ^{[1
]}

Matsuyama, Naoto ^{[1
]}

Hirano, Koji ^{[1
]}

Satoh, Tetsuya ^{[1
]}

Miura, Masahiro ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 05期

关键词：

GACL3-CATALYZED ORTHO-ETHYNYLATION; MEDIATED DIRECT ARYLATION; DIRECT C-2 ARYLATION; H BOND ACTIVATION; C-H; CARBON-HYDROGEN; PALLADIUM; FUNCTIONALIZATION; (HETERO)ARENES; ALKENYLATION;

D O I：

10.1021/jo9025622

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct alkynylation reaction of 1,3,4-oxadiazoles with alkynyl bromides efficiently proceeds In the presence of a copper catalyst at room temperature to create the corresponding heteroaryl-alkynyl linkage in good yields. This direct coupling provides a rapid and convergent access to oxadiazole core pi-conjugated systems.

引用

页码：1764 / 1766

页数：3

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