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MECHANISMS OF DISEASE Alzheimer's Disease

被引：3492
作者：
Querfurth, Henry W. [1 ,2 ,3 ,4 ]
LaFerla, Frank M. [5 ]
机构：
[1] Rhode Isl Hosp, Dept Neurol, Providence, RI 02903 USA
[2] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA
[3] Tufts Med Ctr, Dept Neurol, Boston, MA USA
[4] Caritas St Elizabeths Med Ctr, Dept Neurol, Brighton, MA USA
[5] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 362卷 / 04期
关键词：
AMYLOID-BETA-PROTEIN; NICOTINIC ACETYLCHOLINE-RECEPTOR; INSULIN-DEGRADING ENZYME; BLOOD-BRAIN-BARRIER; GENOME-WIDE ASSOCIATION; LONG-TERM POTENTIATION; NEURONAL CELL-DEATH; A-BETA; MOUSE MODEL; PRECURSOR PROTEIN;
D O I：
10.1056/NEJMra0909142
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：329 / 344
页数：16
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  • [71] The atorvastatin/donepezil in Alzheimer's disease study (LEADe): Design and baseline characteristics
    Jones, Roy W.
    Kivipelto, Miia
    Feldman, Howard
    Sparks, Larry
    Doody, Rachelle
    Waters, David D.
    Hey-Hadavi, Judith
    Breazna, Andrei
    Schindler, Rachel J.
    Ramos, Harry
    [J]. ALZHEIMERS & DEMENTIA, 2008, 4 (02) : 145 - 153
  • [72] Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP
    Kamal, A
    Almenar-Queralt, A
    LeBlanc, JF
    Roberts, EA
    Goldstein, LSB
    [J]. NATURE, 2001, 414 (6864) : 643 - 648
  • [73] APP processing and synaptic function
    Kamenetz, F
    Tomita, T
    Hsieh, H
    Seabrook, G
    Borchelt, D
    Iwatsubo, T
    Sisodia, S
    Malinow, R
    [J]. NEURON, 2003, 37 (06) : 925 - 937
  • [74] Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form
    Kanemitsu, H
    Tomiyama, T
    Mori, H
    [J]. NEUROSCIENCE LETTERS, 2003, 350 (02) : 113 - 116
  • [75] Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Kayed, R
    Head, E
    Thompson, JL
    McIntire, TM
    Milton, SC
    Cotman, CW
    Glabe, CG
    [J]. SCIENCE, 2003, 300 (5618) : 486 - 489
  • [76] 4-hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
    Keller, JN
    Mark, RJ
    Bruce, AJ
    Blanc, E
    Rothstein, JD
    Uchida, K
    Waeg, G
    Mattson, MP
    [J]. NEUROSCIENCE, 1997, 80 (03) : 685 - 696
  • [77] Inducible expression of tau repeat domain in cell models of tauopathy - Aggregation is toxic to cells but can be reversed by inhibitor drugs
    Khlistunova, I
    Biernat, J
    Wang, YP
    Pickhardt, M
    von Bergen, M
    Gazova, Z
    Mandelkow, E
    Mandelkow, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (02) : 1205 - 1214
  • [78] Midlife vascular risk factors and Alzheimer's disease in later life:: longitudinal, population based study
    Kivipelto, M
    Helkala, EL
    Laakso, MP
    Hänninen, T
    Hallikainen, M
    Alhainen, K
    Soininen, H
    Tuomilehto, J
    Nissien, A
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2001, 322 (7300): : 1447 - 1451
  • [79] Oxidative stress, cell cycle, and neurodegeneration
    Klein, JA
    Ackerman, SL
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (06) : 785 - 793
  • [80] Targeting small Aβ oligomers:: the solution to an Alzheimer's disease conundrum?
    Klein, WL
    Krafft, GA
    Finch, CE
    [J]. TRENDS IN NEUROSCIENCES, 2001, 24 (04) : 219 - 224
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